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KMID : 1098420150230020144
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Korean Journal of Medicinal Crop Science
2015 Volume.23 No. 2 p.144 ~ p.149
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Effect of Immature Citrus sunki Peel Extract on Neuronal Cell Death
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Ko Woon-Chul
Lee Sun-Ryung
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Abstract
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The peel of Citrus sunki exhibits multiple biological activities such as anti-oxidant, anti-inflammation and anti-obesity, but little is known about neurodegeneration-related activities. In this study, we investigated the protective effect of ethanolic extract from both immature and mature Citrus sunki peel on neuronal cell death. Treatment of the neuroblastoma cell line SH-SY5Y with MPP+, an inducer of Parkinson disease model, increased cell death in a dose dependent manner. Increased levels of active caspase-3 and cleaved PARP were detected. Treatment with immature Citrus sunki peel extract
significantly reduced MPP+ -induced neurotoxicity. Cytoprotection with immature Citrus sunki peel extract was associated
with a decrease in caspase-3 activation and PARP cleavage. In contrast, mature Citrus sunki peel extract had no significant effects. These data suggest that immature Citrus sunki peel extract may exert anti-apoptotic effect through the inhibition of caspase-3 signaling pathway on MPP+ -induced neuronal cell death.
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KEYWORD
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Citrus sunki, Apoptosis, Parkinson Disease, MPP+
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